Gender-related differences in IgA nephropathy; an eleven-year experience according to revised Oxford classification

Introduction: IgA nephropathy (IgAN) is a common glomerular disease characterized by dominant or co-dominant granular deposits in the mesangial areas. Objectives: This study aimed to determine possible gender-related differences IgAN at single center Iran. Patients and Methods: All renal biopsy-proven cases of during last 11 years (2009-2020) were studied. kidney biopsies had two samples for immunofluorescence light microscopy. Renal reviewed using recently revised Oxford classification IgAN. In addition Oxford-MEST morphologic variables, other data consisting age, gender, serum creatinine level proteinuria within 24 hours time biopsy collected. The analyzed SPSS version 21.0. Results: included 246 patients with mean age 38.23±13.71 male prevalence 67.1% (n=161). ± SD values 24-hour 1.47±1.06 mg/dL 1753.63±1049.418 mg/d, respectively. Analysis regarding creatinine, quantity proteinuria, number sclerotic glomeruli, percent interstitial fibrosis showed only be significantly higher males than females (P=0.017). Moreover, was (P=0.047). Our that have more segmental sclerosis (P=0.023) significant IgM (P=0.003). scores IgA, IgG, C3 deposited immunological reactants not substantially different between (P>0.05). Conclusion: males. Males also on biopsies. Larger-scale research needed confirm our results.